Dr. Sperling is a Professor of Medicine, Associate Vice Chair for Research in the Dept of Medicine, Director of the Respiratory Biology Training Grant, and the Faculty Director of the Cytometry and Antibody Technology Core. She has previously had the honor of serving as a regular member of the NIH Study Section Hypersensitivity, Autoimmunity, and Immune-mediated Diseases (HAI) and Lung Cellular and Molecular Immunology (LCMI). Dr. Sperling's research program focuses on the role of the immune system in lung diseases in mouse models and human disease. In mouse models, they have made significant contributions to our understanding of how T cell costimulatory molecules influence inflammation and disease, the role of lung dendritic cells in the initiation of type 2 inflammatory responses, and the regulation of inflammation resolution in allergic asthma. Dr. Sperling's recent human translational studies have addressed how genetically regulated costimulatory molecule expression regulates atopy, how asthma-protective environment affect immune profiles and function in farm children, and how T cells in the blood and lungs of patients with idiopathic pulmonary fibrosis differ from controls and correlate with lung function.